Advances in the metabolomic signatures in bone osteoporosis and cancer

Metabolomics in Bone Osteoporosis

Authors

  • Raja Ganesan Institute for Liver and Digestive Diseases, College of Medicine, Hallym University, Chuncheon 24253, Korea.
  • Vasantha-Srinivasan Prabhakaran Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India, 602105.
  • Arumugam Balasubramanian Transfusion Medicine, Department of Pathology, Harvard Medical School, Boston, MA, USA.

DOI:

https://doi.org/10.51607/22331360.2022.71.3.301

Keywords:

Biomarkers, bone mineral density, metabolomics, osteoporosis, taurine

Abstract

Metabolomic technologies have evolved rapidly contributing the basic metabolic activity of bone diseases. The identification of the metabolic determinant of osteoporosis and bone mass disorder is not yet summarized. Metabolic signalling activity of bone tissue regeneration is crucial for mesenchymal cell differentiation, scaffolds, bone remodelling and metabolism. Numerous of discovered metabolites merit functional follow-up studies to elucidate their role of bone metabolism. The knowledge gained from metabolome investigations is helping to redefine bone disease, find new medication targets for skeletal disorders, and identify biomarkers that are predictive of bone disease. Based on their safety, effectiveness, and cost performance, researchers are becoming more and more interested in creating novel treatments for osteoporosis employing mesenchymal stem cells-based metabolites therapy. The personalized management of osteoporosis-based metabolomics profiling may benefit from advancements in both diagnostic and therapeutic approaches.

Author Biographies

Raja Ganesan, Institute for Liver and Digestive Diseases, College of Medicine, Hallym University, Chuncheon 24253, Korea.

Institute for Liver and Digestive Diseases, College of Medicine, Hallym University, Chuncheon 24253, Korea.

Vasantha-Srinivasan Prabhakaran, Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India, 602105.

Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India, 602105.

Arumugam Balasubramanian, Transfusion Medicine, Department of Pathology, Harvard Medical School, Boston, MA, USA.

Transfusion Medicine, Department of Pathology,

Harvard Medical School, Boston, MA, USA.

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Published

2022-12-18

Issue

Section

Review Article (peer review)